Team Develops 「Coronavirus-clearing」 Concoction 預防新冠肺炎 陽明交大開發中藥「淨冠方」

Can Chinese medicine be used to treat COVID-19? National Yang Ming Chiao Tung University researchers gave five herbal medicines to 1,000 frontline medical personnel, with ninety percent of them reporting positive feeback.


This is a decoction comprising the five herbal medicines of Baikal skullcap, Chinese thorowax root, huoxiang, forsythia suspensa, and magnolia. It is called "coronavirus-clearing concoction," and was developed by a team at National Yang Ming Chiao Tung University's Institute of Traditional Medicine for use against COVID-19. In 2020, the researchers gave the concoction to over 1,000 medical personnel. Many reported an improvement in cold symptoms such as throat pain, coughing, and headaches.

Hsu Chung-hua, Professor, Institute of Traditional Medicine, NYCU: “Using it in high-risk situations can lead to weakening, purifying, preventing infections, and even reducing symptoms.”

The team conducted animal tests to determine the scientific mechanism. It found that two days after ingesting the concoction, the expressions of ACE2 and TMPRSS2 in the lung cells of mice were significantly reduced. These two proteins that are found on cell membranes are the receptors that the coronavirus binds to.

Lin Tung-yi, Asst. Professor, Institute of Traditional Medicine, NYCU: “The concoction first treats lung cells or host cells, and then the viral infection, and the infection ability will be weakened.”

The concoction can be delivered into the nasal cavity as vapor for rapid absorption in the lungs and improvement in cold symptoms. The team says it can make viruses weaker and prevent infection. It adds that the concoction can't replace vaccines, and the university will authorize it for public use in line with the method used for the AZ vaccine.

 

 

 

擺在桌上這五種草藥,包括黃芩、柴胡、霍香、連翹、厚朴,熬煮之後就成了「淨冠方」,這是陽明交大傳統醫藥研究所團隊,開發用來對抗新冠肺炎。這帖藥2020年時,提供給超過千位醫護人員使用,當時受試者認為,包括喉嚨痛、咳嗽、頭痛等類感冒症狀獲得改善。

陽明交大傳統醫藥研究所教授許中華說:「在高危險狀況下來使用,來達到弱化跟淨化跟預防感染,甚至能夠降低這些症狀的一些設計理念。」

為了探究這帖中藥背後的科學機轉,研究團隊進行動物實驗,證實在餵食淨冠方兩天後,老鼠體內的肺臟細胞ACE2與TMPRSS2表現量會顯著降低,而這兩個細胞膜上的蛋白,正是冠狀病毒跟細胞結合的受體。

陽明交大傳統醫藥研究所副教授林東毅表示:「淨冠方先給予肺臟細胞處理,或是一些宿主細胞處理之後,再給病毒感染,其實它的感染效果就會變差。」

此藥物也可以通過蒸氣法由鼻腔吸收,藥材可迅速進入鼻腔跟肺部,來改善感冒症狀。研究團隊指出,藉由此中藥方可減低弱化病毒、輔助預防感染,不過仍強調,淨冠方不能取代疫苗。後續校方將循AZ疫苗的公益模式來授權,造福更多民眾。

 

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