Researchers Find New Way to Treat Asthma|中研院研究 青春痘細菌可預防.治療氣喘


Many people in Taiwan suffer from asthma, and around 10 percent cannot be treated with steroids due to drug resistance. The good news is, a new study has found that corticosteroid-resistant asthma can be treated using an immunomodulatory microparticle-based approach derived from bacteria that causes acne.


The asthma prevalence among children in Taiwan is very high. In the past, it was believed that allergens promoted the activation of T-cells, resulting in asthma, and therefore asthma was treated with steroids. However, around 10 percent of asthmatics have corticosteroid-resistant asthma. A new study conducted by the Academia Sinica's Institute of Biomedical Sciences said recent studies have implicated group 2 innate lymphoid cells (ILC2) in asthma development and exacerbation, and ILC2-induced airway hyperreactivity and lung inflammation can be suppressed by TLR9 immunostimulatory CpG motifs from acne bacteria.

We used this microparticle, which contains the TLR9 ligand. It creates more interferons, and these interferons suppress this ILC-2 cell that we have studied for a long time. Once ILC-2 cells are suppressed, lung inflammation and asthma are also suppressed.

The researchers used a microparticle derived from the bacteria P. acne, which is the bacteria that causes acne. The immunomodulatory microparticle that they developed was administered to mice through inhalants, and the result was the suppression of the asthma symptoms caused by ILC-2 cells. It was also effective in suppressing asthma produced by T-cells, and is safe, harmless, and without side effects.

In both mice and humanized mice, which are those with human cells injected, the asthma flare-up rate was effectively reduced.

The Academia Sinica says immunomodulatory microparticles were previously used in medication to treat multiple sclerosis patients. This was the first time they were used to treat asthma. This study was published in the March edition of international periodical "The Journal of Allergy and Clinical Immunology." The drugs derived from this study are expected to hit the market in 10 years' time.



國內兒童氣喘盛行率相當高,過去醫界認為是免疫T細胞受到過敏刺激造成氣喘,因此大多採用類固醇治療,不過約有一成患者會產生抗藥性,中研院最新研究發現,氣喘也與第二型先天免疫細胞有關,而且青春痘的細菌,可以有效治療及預防氣喘發作。

中研院生醫所助研究員 張雅貞表示:「我們就用這個微粒子呢!它裡面載有這個TLR9的配體,製造更多的一些干擾素,那這些干擾素呢!都會抑制掉這個,我們長期研究這個ILC2這個細胞,所以因為抑制掉ILC2,也進而抑制掉,肺部的發炎以及氣喘。」

中研院研究團隊利用「痤瘡桿菌」,也就是大家熟悉的青春痘菌、所研發的「免疫調控微粒子」,用吸入劑投藥到小鼠身上做實驗,結果發現,不僅可以抑制第二型先天免疫細胞所造成的氣喘症狀,另外對於T細胞造成的氣喘也有療效,不僅安全無害,也無副作用。

中研院生醫所助研究員 張雅貞表示:「老鼠的模式,以及在人體化的老鼠中,就是把人的細胞打到老鼠裡面去,看牠的氣喘的發作率,也發覺有非常有效的下降。」

中研院強調,過去這種「免疫調控微粒子」是應用在多發性硬化症患者的藥物上,這次是全球首度應用在氣喘治療,也獲得印證,而這項最新研究成果,今年3月已刊登在國際「過敏和臨床免疫學雜誌」,新藥預計十年內可以問世。

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